6PGD-IN-2 is a non-competitive inhibitor of 6-phosphogluconate dehydrogenase (6PGD) with an IC50 value of 5.1 µM. It disrupts 6PGD oligomerization in a substrate-dependent manner and induces the production of NADPH and Ru-5-P while reducing DNA synthesis in A549 cells. 6PGD-IN-2 is applicable in research on non-small cell cancer and liver cancer.
Target:
DNA/RNA Synthesis
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