MMRi6 is an inhibitor of the Mdm2-MdmX RING domain, capable of disrupting Mdm2-MdmX RING-RING interactions in vitro. It inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated polyubiquitination of p53 without affecting NEDD4-1 autoubiquitination. In wt-p53 Emu-myc lymphoma cells, MMRi6 induces p53 stabilization and accumulation, as well as PARP cleavage. It inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells, with IC50 values of approximately 0.5 µM and 3 µM, respectively. MMRi6 is applicable in leukemia/lymphoma research.
Molecular Weight:
396.27
CAS Number:
[709009-15-4]
Formula:
C21H15Cl2N3O
Target:
PARP|||MDM-2/p53
T212097
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