Acid Ceramidase-IN-3, CAS [[2907705-12-6]] Preis auf Anfrage

Product Overview

• Article Name: Acid Ceramidase-IN-3, CAS [[2907705-12-6]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T212108
• Supplier Catalog Number: T212108
• Alternative Catalog Number: TGM-T212108-10MG,TGM-T212108-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

Acid Ceramidase-IN-3 is an inhibitor of acid ceramidase (aCDase). It shows a pIC50 of 8.5 in enzymatic assays and a pIC50 of 6.8 in A375 melanoma cell assays for aCDase enzyme activity inhibition. Acid Ceramidase-IN-3 promotes hepatic stellate cell (HSC) inactivation, measured by dose-dependent reduction of COL1A1 and ACTA2 levels. Additionally, it inhibits aCDase activity in HSCs, facilitating their inactivation and inhibiting YAP/TAZ nuclear localization. The compound enhances the expression of dynein/kinesin-related proteins (NDE1, NDEL1, KIF3B, KIF15) while reducing the expression of proteins related to various signaling pathways (SARM1, RGAP1, PDGF-D, PDGFR-B). Acid Ceramidase-IN-3 is valuable for fibrosis disease research.

Product Properties

• Molecular Weight: 443.51
• CAS Number: [2907705-12-6]
• Formula: C27H26FN3O2
• Target: Others

Images

T212108