BAL-1516 is a brain-penetrant and highly selective NLRP3 inhibitor (IC50=14.2 nM). It significantly inhibits the release of interleukin-1beta and interleukin-18 in microglial neuroinflammation models (IC50=11-59 nM). BAL-1516 holds potential for research in neurodegenerative diseases, such as Alzheimers and Parkinsons, as well as systemic inflammatory disorders.
Target:
NOD-like Receptor (NLR)
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