TD034 is a selective, reversible, non-covalent inhibitor of HDAC11, with an IC50 of 5.1 nM and a Ki of 1.5 nM. It does not inhibit other HDACs or sirtuins. TD034 inhibits the desuccinylation of SHMT2 (a substrate of HDAC11) and lowers YAP1 levels by inhibiting HDAC11. TD034 is applicable for lung cancer research.
Molecular Weight:
757.01
CAS Number:
[3030718-42-1]
Formula:
C45H64N4O6
Target:
HDAC|||YAP
T212192
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