SOS1-IN-21, CAS [[2767633-04-3]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T212275
Supplier Catalog Number:
T212275
Alternative Catalog Number:
TGM-T212275-10MG,TGM-T212275-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC50 value of 15 nM. As a guanine nucleotide exchange factor (GEF), SOS1 activates KRAS by facilitating the conversion of GDP to GTP. SOS1-IN-21 demonstrates potent antiproliferative activity, with IC50 values of 16 nM for NCI-H358 cells and 17 nM for Mia Paca-2 cells. It exhibits significant antitumor activity in Mia Paca-2 xenograft models and is useful for researching KRAS-mutated tumors, such as pancreatic cancer.
Molecular Weight:
493.52
CAS Number:
[2767633-04-3]
Formula:
C25H30F3N3O4
Target:
Raf
T212275
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