alphaMbeta2integrinagonist-1 (Compound 8) is a highly selective alphaMbeta2 integrin agonist with anti-inflammatory properties (EC50=1.4 nM). It activates integrin-mediated cell adhesion and the JNK/ERK signaling pathway. Additionally, alphaMbeta2integrinagonist-1 induces polarization of tumor-associated macrophages and enhances antitumor T-cell immune responses. This compound holds potential for research in cancer and chronic inflammatory diseases such as pancreatic cancer and rheumatoid arthritis.
Target:
Integrin
* VAT and and shipping costs not included. Errors and price changes excepted
