GNE-5152 is a straight-chain SARM1 base exchange (BE) inhibitor. Under mild activation conditions, GNE-5152 persistently activates SARM1 at sub-inhibitory concentrations, which synergistically enhances NAD consumption, leading to axonal degeneration and neurodegeneration, and releases neurofilament light chain (NfL) in cortical neurons. GNE-5152 is applicable in neurodegenerative disease research.
Molecular Weight:
365.38
CAS Number:
[3080315-83-6]
Formula:
C21H17F2N3O
Target:
TLR
T212340
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