IL-6-IN-2 (Compound 15) is an inhibitor of the interaction between IL-6 and IL-6R proteins. The compounds binding free energy (deltaG) is -36.50 kcal/mol. In its binding with IL-6, the contributions from Lys66, Phe74, Gln175, Ser176, and Arg179 are -1.10, -8.68, -6.91, -3.69, and -1.72 kcal/mol, respectively. IL-6-IN-2 exhibits low gastrointestinal (GI) absorption rates.
Molecular Weight:
440.49
CAS Number:
[296790-70-0]
Formula:
C26H24N4O3
Target:
Interleukin
T212342
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