AVI-4206 is a selective Mac1 inhibitor with an IC50 of 64 nM for inhibiting Mac1s catalytic activity. It effectively reduces SARS-CoV-2 viral replication, restores interferon response, and demonstrates survival benefits in animal models infected with SARS-CoV-2. AVI-4206 is applicable for research related to SARS-CoV-2 infections.
Target:
SARS-CoV
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