QPyN16Th is an N-palmitoylated cationic thiazolidine antibiotic. It exhibits selective activity against Gram-positive bacteria such as Enterococcus faecalis, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus (MRSA), with a MIC of 1.95 µM for Gram-negative bacteria. QPyN16Th can induce membrane permeabilization and depolarization in MRSA, along with ROS generation. It improves survival rates in a zebrafish model with intramuscular MRSA infection.
Target:
Antibiotic|||Antibacterial
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