HIF-1alpha-IN-8 is an orally active inhibitor of HIF-1alpha with an IC50 of 2.02 µM. It effectively suppresses the expression of inflammatory factors such as IL-6 and NO, reduces hypoxia-induced ROS production and apoptosis in C8-D1A cells, and inhibits the HIF-1alpha/IKKalpha/NF-kappaB signaling pathway. Additionally, it decreases the expression of proteins related to blood-brain barrier permeability. In a high-altitude cerebral edema (HACE) mouse model, HIF-1alpha-IN-8 lowers brain water content and oxidative stress levels. This compound is suitable for researching high-altitude cerebral edema (HACE).
