FAZ-3532 is a potent G3BP inhibitor that binds to G3BP1 with a dissociation constant (Kd) of 0.54 µM, inhibiting the co-condensation of G3BP1, Caprin1, and RNA, and preventing the formation of intracellular stress granules. It selectively targets the protein-protein interactions within the G3BP1 NTF2L domain without affecting its dimerization or RNA binding, making it an effective tool for studying the immunological role of stress granules during viral infections.
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