SB405483 is a CRBN (cereblon) orthosteric ligand-binding enhancer that promotes the ubiquitination and proteasomal degradation of CRBN substrates (such as CK1alpha, Wee1, and IKZF1/3) by stabilizing the CRBN protein conformation and enhancing its binding affinity for substrates. SB405483 can be used in cancer research, such as in multiple myeloma and acute myeloid leukemia.
Molecular Weight:
360.37
Purity:
99.70%
Formula:
C20H16N4O3
Target:
Ligands for E3 Ligase
T212820
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