Opitor-0 is a highly selective OPA1 GTPase inhibitor with an IC50 of 3 µM. Opitor-0 disrupts the stability of OPA1 oligomers, triggering mitochondrial cristae remodeling and fragmentation, which leads to massive release of cytochrome c and subsequently induces apoptosis. In anticancer studies, Opitor-0 has been shown to exhibit synergistic effects when combined with the Bcl-2 inhibitor ABT-737 or Venetoclax.
Molecular Weight:
519.62
Purity:
98.61%
Formula:
C30H25N5O2S
Target:
Others
T212834
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