LMDP10 is an orally active 3-aminoquinazoline derivative that activates the Keap1-Nrf2 pathway. It binds to Keap1, inhibiting the Keap1-Nrf2 interaction and subsequently activating the Nrf2 pathway. This leads to increased levels of Nrf2, SOD, and GSH, while reducing MDA and TNF-alpha levels. As a result, LMDP10 alleviates neurodegeneration and improves memory in Alzheimers disease (AD) rat models. LMDP10 is applicable for Alzheimers disease (AD) research.
Molecular Weight:
492.51
CAS Number:
[2760446-25-9]
Formula:
C29H21FN4O3
Target:
Nrf2
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