PI4Kbeta-IN-1 is an orally active selective inhibitor of PI4Kbeta with an IC50 of 0.9 nM. It exhibits inhibitory activity across all stages of the P. falciparum lifecycle, including the blood, liver, and transmission phases. In mouse models infected with Plasmodium falciparum, PI4Kbeta-IN-1 demonstrates significant antimalarial efficacy. This compound is applicable for research on malaria caused by Plasmodium falciparum.
Target:
Parasite|||PI4K
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