LMP-420 is a selective inhibitor of tumor necrosis factor-alpha (TNF-alpha). It reduces the release of pro-inflammatory cytokines, such as IL-1beta and IL-2, while inducing the expression of anti-inflammatory cytokine IL-10, and anti-apoptotic molecules SOCS-1 and Mn-SOD. LMP-420 also downregulates chemokines like IP-10 and MCP-1, which decreases immune cell infiltration. This compound shows potential for research into type 1 diabetes, inflammatory diseases such as colitis, and HIV-mycobacterium tuberculosis co-infection.
Molecular Weight:
283.52
CAS Number:
[473870-63-2]
Formula:
C10H15BClN5O2
Target:
TNF|||Interleukin
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