Glycosyltransferase-IN-2 (Compound 20) is an inhibitor of glycosyltransferase with broad-spectrum antiviral activities against coronaviruses. It shows IC50 values of 11.3 µM for MHV, 5.5 µM for HCoV-NL63, and approximately 16.2 µM for SARS-CoV-2. This compound can interfere with coronavirus infectivity, alter viral protein glycosylation, inhibit interaction with the ACE2 receptor, and suppress secretion of cytotoxic viral particles (SC-VLP) and RNA replication. Glycosyltransferase-IN-2 is utilized in coronavirus infection research.
