PX20350 is an FXR agonist with EC50 values of 83 nM for mFXR and 10 nM for hFXR. It significantly induces NDRG2 mRNA expression. PX20350 effectively inhibits the growth and metastasis of liver tumor cells (SK-GI-18 cells) and exhibits antitumor activity in orthotopic xenograft mouse models.
Molecular Weight:
592.4
CAS Number:
[1198085-23-2]
Formula:
C28H22Cl2F3N3O4
Target:
FXR
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