Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.
Molecular Weight:
385.6
Purity:
98.05%
CAS Number:
[125973-56-0]
Formula:
C20H27NO3Si2
Target:
Apoptosis|||Retinoid Receptor|||CDK
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