AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 µM Cinnamaldehyde with an IC50 of 3.1 µM and 4.5 µM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freunds adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 µM AITC in a concentration-dependent manner (IC50= 10.3 µM).
Molecular Weight:
209.67
Purity:
90.00%
CAS Number:
[55224-94-7]
Formula:
C11H12ClNO
Target:
TRP/TRPV Channel
T21543
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