KN-93 hydrochloride is a cell-permeable, reversible, and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. KN-93 hydrochloride induces G1 cell cycle arrest in 95% of treated cells after two days, with the arrest being reversible, one day after KN-93 withdrawal, a peak of cells progresses into S and G2-M phases, providing a robust tool for cell cycle regulation studies and mechanistic investigation of CaMKII-dependent signaling.
Molecular Weight:
537.5
Purity:
99.99%
CAS Number:
[1956426-56-4]
Formula:
C26H30Cl2N2O4S
Target:
CaMK|||Autophagy
T21557
T21557
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