Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3 binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3 has antitumor activity.
Molecular Weight:
581.49
Purity:
98.13%
CAS Number:
[548472-68-0]
Formula:
C30H30Cl2N4O4
Target:
E1/E2/E3 Enzyme|||MDM-2/p53
T2158
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