SB 203580 hydrochloride (Adezmapimod hydrochloride) is a selective, ATP-competitive p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy and inhibits SAPK2a/p38, SAPK2b/p38beta2, LCK, GSK3beta, and PKBalpha. SB 203580 hydrochloride has been shown to be useful in antiretroviral therapy. 203580 hydrochloride inhibits amphoteric mechanical anomalous pain in a mouse model of antiretroviral-induced neuropathic pain.
Molecular Weight:
413.9
Purity:
97.79%
CAS Number:
[869185-85-3]
Formula:
C21H17ClFN3OS
Target:
Autophagy|||Mitophagy|||p38 MAPK|||Src
T21675
T21675
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