BCMA CARmRNA encodes a CAR protein targeting human BCMA and induces temporary CAR expression in T cells without the necessity for permanent genetic modification. It is used in cancer research as it targets BCMA, a member of the tumor necrosis factor receptor superfamily 17 (TNFRSF17), also known as B-cell maturation antigen (CD269). This receptor supports B-cell survival and plays a role in regulating humoral immunity. Notably, BCMA is highly expressed in multiple myeloma and serves as a biomarker for its diagnosis.
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