MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 µM for iNOS, 110 µM for ecNOS, and 60 µM for bNOS in tissue homogenates. It is notably effective as a peroxynitrite scavenger and blocks peroxynitrite-triggered oxidative mechanisms. Furthermore, this compound offers protective benefits across various experimental inflammation prototypes, such as ischemia/reperfusion injury, hemorrhagic shock, periodontitis, inflammatory bowel disease, and both endotoxic and septic shock.
Molecular Weight:
336.44
Purity:
99.81%
CAS Number:
[3979-00-8]
Formula:
C6H20N6O4S3
Target:
NOS|||NO Synthase
T21967
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