JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 µM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies.
Molecular Weight:
440.56
Purity:
99.86%
CAS Number:
[1256375-38-8]
Formula:
C27H24N2O2S
Target:
Apoptosis|||Sirtuin
T22094
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