Varenicline Hydrochloride (CP 526555) is an orally active partial agonist of the alpha4beta2 nicotinic acetylcholine receptor (alpha4beta2 nAChR, IC50 = 250 nM), which is recognized as the principal mediator of nicotine dependence, and its pharmacological effect is critical in modulating addictive behaviors associated with nicotine exposure. Varenicline Hydrochloride (CP 526555) blocks the direct agonist effects of nicotine on nicotinic acetylcholine receptors while simultaneously stimulating these receptors in a more moderate and controlled manner, making it a widely used research compound in smoking cessation.
Molecular Weight:
247.72
Purity:
99.85%
CAS Number:
[230615-23-3]
Formula:
C13H14ClN3
Target:
Others|||AChR
T23502
T23502
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