PF-06807656 is insensitive to the introduction of the N171D mutation in the ROMK conduction pore that greatly diminishes the activity of other small-molecule inhibitors. PF-06807656 is an effective ROMK inhibitor (Tl+ flux IC50 = 160 nM).
Molecular Weight:
449.91
Formula:
C19H20ClN5O4S
Target:
Others
T24623
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