TP0427736 is a potent and selective inhibitor of ALK5 with an IC50 of 2.72 nM, 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-beta-induced growth inhibition in human outer root sheath cells and elongates the anagen phase in mouse hair follicles.
Molecular Weight:
298.39
Purity:
0.9767
CAS Number:
[864374-00-5]
Formula:
C14H10N4S2
Target:
TGF-beta/Smad
T24897
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