TSI-01, a pro-inflammatory phospholipid mediator, is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: LPCAT1, predominantly expressed in lungs, and LPCAT2, expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50 values of 0.47 µM and 3.02 µM for human LPCAT2 and LPCAT1, respectively). At 60 µM, it suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages.
Molecular Weight:
328.15
Purity:
99.87%
CAS Number:
[704878-75-1]
Formula:
C14H11Cl2NO4
Target:
Others|||PAFR
T24904
T24904
* VAT and and shipping costs not included. Errors and price changes excepted
