Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/3 nM), similar activity against PDGFRbeta and c-Kit, selective more for VEGFR than PDGFR-alpha (36-fold), CSF-1R (110-fold), and Flt3 (1000-fold) in HUVEC cells.
Molecular Weight:
450.51
Purity:
97.21%
CAS Number:
[288383-20-0]
Formula:
C25H27FN4O3
Target:
Autophagy|||PDGFR|||c-Kit|||VEGFR|||FLT
T2500
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