Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1, intracellularly, this agent is highly polyglutamylation and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis.
Molecular Weight:
477.47
CAS Number:
[1320211-70-8]
Formula:
C23H23N7O5
Target:
Others
T25980
* VAT and and shipping costs not included. Errors and price changes excepted
