Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.
Molecular Weight:
438.3
Purity:
98.87%
CAS Number:
[131740-09-5]
Formula:
C21H21Cl2NO5
Target:
HIV Protease|||Autophagy|||CDK
T2615
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