LY2811376, an orally available non-peptidic beta-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Abeta secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.
Molecular Weight:
320.36
Purity:
95.23%
CAS Number:
[1194044-20-6]
Formula:
C15H14F2N4S
Target:
BACE|||Beta-Secretase|||Beta Amyloid
T2639
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