AGI-026 (AGI-12026) is a novel and potent dual inhibitor of the mutant isocitrate dehydrogenase mIDH1/2 with the advantages of oral administration and penetration of the blood-brain barrier, with a drug concentration to plasma concentration ratio (brain/plasma ratio) of 1.5 in brain tissue, and the ability to reduce the accumulation of the carcinogenic metabolite d-2-hydroxyglutarate (2-HG), which is used in the study of mIDH gliomas.
Molecular Weight:
443.35
Purity:
99.86%
CAS Number:
[1446501-77-4]
Formula:
C18H15F6N7
Target:
Isocitrate Dehydrogenase (IDH)
T26575
T26575
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