Apomine (SR-9223i), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase and stimulates low-density lipoprotein receptor activity. Apomine enhances the antitumor effect of lovastatin on myeloma cells by downregulating 3-hydroxy-3-methylglutaryl-CoA reductase.
Molecular Weight:
562.66
Purity:
98.80%
CAS Number:
[126411-13-0]
Formula:
C28H52O7P2
Target:
Apoptosis|||HMG-CoA Reductase
T26644
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