PKUMDL-WQ-2201 is a PHGDH non-NAD-competing allosteric inhibitor with micromolar potency against wild-type and mutant PHGDH enzymes, effectively suppressing de novo serine biosynthesis in cancer cells and reducing tumor growth, PKUMDL-WQ-2201 provide a metabolic intervention strategy for studying serine-dependent tumor metabolism.
Molecular Weight:
351.81
CAS Number:
[592474-91-4]
Formula:
C15H14ClN3O3S
Target:
Dehydrogenase
T28425
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