Pradefovir (Remofovir) is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. Pradefovir is also a liver-targeted prodrug of adefovir. After metabolic activation, Pradefovir was converted to PMEA (9-(2-phosphonylmethoxyethyl)adenine) in human liver microsomes with a K(m) of 60 microM, a maximum rate of metabolism of 228 pmol/min/mg protein, and an intrinsic clearance of about 359 ml/min.
Molecular Weight:
423.79
Purity:
0.975
CAS Number:
[625095-60-5]
Formula:
C17H19ClN5O4P
Target:
Cytochromes P450|||HBV
T28449
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