PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 µM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.
Molecular Weight:
276.72
CAS Number:
[86811-36-1]
Formula:
C14H13ClN2O2
Target:
ROCK|||ERK|||CDK
T28469
T28469
* VAT and and shipping costs not included. Errors and price changes excepted
