Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 1.5 nM, and shows topical anti-inflammatory activity in a mouse model of skin inflammation.
Molecular Weight:
460.37
Purity:
99.59%
CAS Number:
[154413-61-3]
Formula:
C23H19Cl2NO3S
Target:
Calcium Channel|||Leukotriene Receptor|||LTR
T28974
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