Spermine (Neuridine) is an endogenous polyamine in the human body. As a direct free radical scavenger, it exhibits antiviral activity and protects DNA from free radical damage, it is also a key regulator of cell proliferation, differentiation, and apoptosis. Spermine inhibits certain bacteria, particularly strains of Staphylococcus aureus. Spermine induces striatal neurotoxicity in a dose-dependent manner. Spermine reversibly inhibits DNA synthesis, mixed lymphocyte reactions, and the induction of cytolytic lymphocyte reactions in primary cultures of mouse splenocytes.
