JH-IX-179 is a novel type I ATP competitive and highly selective FLT3 inhibitor. JH-IX-179 is much more selective for FLT3 and FLT3 mutants than for Kronani. In addition, JH-IX-179 showed little human serum protein binding and effectively inhibited autophosphorylation of FLT3 and activity of downstream signaling molecules of FLT3-D835Y and FLT3-ITD.
Molecular Weight:
436.52
Formula:
C26H24N6O
Target:
Others
T32288
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