SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. It exhibits antitumor effects in multiple animal models and Y cell lines.
Molecular Weight:
420.52
Purity:
>99.99%
CAS Number:
[222716-34-9]
Formula:
C24H24N2O3S
Target:
Apoptosis|||E1/E2/E3 Enzyme
T3317
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