Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 µM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 µM, BT474 cells, 6 µM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
Molecular Weight:
740.92
Purity:
99.61%
CAS Number:
[41059-79-4]
Formula:
C39H64O13
Target:
mTOR|||Cholinesterase (ChE)
T3395
T3395
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