Safrole oxide was found to significantly inhibit neuronal cell growth and induce apoptosis. Safrole oxide elevated the levels of cyclooxygenase 2 (COX-2), interleukin-8 (IL-8) and reactive oxygen species (ROS), which was accompanied by nuclear factor-kappa B (NF-kappaB) nuclear translocation during the transdifferentiation, suggesting safrole oxide may induce endothelial cell transdifferentiation into functional neuron-like cells.
Molecular Weight:
178.18
Purity:
100.00%
CAS Number:
[7470-44-2]
Formula:
C10H10O3
Target:
COX
T34627
T34627
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