Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 2 nM (CLT IC50 = 100 12 nM) and inhibits RBC dehydration with an IC50 of 30 20 nM. Senicapoc is used in the treatment of Sickle Cell Disease and Sickle Cell Anemia.
Molecular Weight:
323.34
Purity:
95.70%
CAS Number:
[289656-45-7]
Formula:
C20H15F2NO
Target:
Potassium Channel
T3528
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