AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 µg/kg/min, respectively. The doses induced the increase in bleeding time at 33 and 100 µg/kg/min for 3- and 13-fold, respectively. Thus, the therapeutic index (TI) was 10 for both compounds.
Molecular Weight:
470.54
Purity:
98.29%
CAS Number:
[919351-41-0]
Formula:
C23H26N4O5S
Target:
P2Y Receptor
T3536
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