beta-Defensin-1 (human) (trifluoroacetate salt)

Product Overview

• Article Name: beta-Defensin-1 (human) (trifluoroacetate salt)
• Biozol Catalog Number: TGM-T35426
• Supplier Catalog Number: T35426
• Alternative Catalog Number: TGM-T35426-100UG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

beta-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2beta-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but not of resistantM. tuberculosisRM22 when used at a concentration of 128 µg/ml.3,4It blocks human and mouse Kv1.3 voltage-gated potassium channels (IC50s = 11.8 and 13.2 µM, respectively).5Overexpression of beta-defensin-1 in the human oral squamous cell carcinoma (OSCC) cell lines HSC-3, UM-1, and SCC-9 increases migration and invasion but not proliferation.6